Thermo Fisher Scientific ZNRF2 Recombinant Rabbit Monoclonal Antibody (JJ0924)
ZNRF2 단백질을 인식하는 재조합 토끼 단클론 항체로, 높은 특이성과 민감도를 제공. Western blot 및 IHC(Paraffin) 실험에 적합. 로트 간 일관성과 동물 유래 성분이 없는 포뮬레이션. 단기 4°C, 장기 -20°C 보관 권장.
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Thermo Fisher Scientific ZNRF2 Recombinant Rabbit Monoclonal Antibody (JJ0924)
Applications and Tested Dilutions
- Western Blot (WB): 1:1,000–1:2,000
- Immunohistochemistry (Paraffin) [IHC (P)]: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JJ0924 |
| Immunogen | Synthetic peptide within Human ZNRF2 aa 162–206 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809754 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
ZNRF2 (zinc and ring finger 2), also known as RNF202, is a 242-amino-acid peripheral membrane protein containing a RING-type zinc finger. It localizes to lysosomes, endosomes, and cell junctions, and is highly expressed in brain tissue.
ZNRF2 functions as an E3 ubiquitin-protein ligase, contributing to neuronal transmission and plasticity. Upon DNA damage, it undergoes phosphorylation, likely mediated by ATR or ATM.
Ubiquitination involves three enzyme classes (E1, E2, E3) that target proteins for degradation, maintaining cellular protein homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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