Thermo Fisher Scientific Claudin 16 Recombinant Superclonal Antibody (10HCLC)
Claudin 16 단백질을 검출하기 위한 Thermo Fisher Scientific의 재조합 Superclonal 항체. 높은 특이성과 민감도를 제공하며, Western blot, IHC, ICC 등 다양한 응용에 적합. 일정한 로트 간 재현성을 보장하는 재조합 항체 기술 적용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 3–4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:100 |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Superclonal |
| Type | Antibody |
| Clone | 10HCLC |
| Immunogen | Peptide corresponding to amino acids 256–277 of human claudin-16 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2532632 |
Product Specific Information
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They consist of multiple recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies.
These antibodies offer consistent performance across lots due to controlled recombinant production, avoiding biological variability typical of polyclonal antibodies.
Formerly referred to as “Recombinant polyclonal antibody”, now rebranded as “Recombinant Superclonal™ antibody” with unchanged physical and functional properties.
Target Information
Tight junction proteins are cell-to-cell adhesion structures in epithelial cells forming the junctional complex with adherens junctions and desmosomes.
Claudin-16, also known as Paracellin-1, is a renal tight junction protein essential for paracellular magnesium resorption. It is localized in the epithelial cells of the thick ascending limb of Henle’s loop (TAL marker) and plays a key role in Mg²⁺ transport.
Deficiency of Claudin-16 can lead to impaired renal magnesium handling and associated cardiovascular and renal dysfunctions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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