Thermo Fisher Scientific ICAM-1 Monoclonal Antibody (MEM-111)
ICAM-1 (CD54) 단백질을 인식하는 MEM-111 마우스 단클론 항체로, 인간, 소, 랫트에 반응합니다. Western blot, IHC, Flow cytometry 등 다양한 응용에 적합하며, Protein A로 정제된 액상 형태입니다. 4°C에서 보관하며 연구용으로만 사용됩니다.
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Thermo Fisher Scientific ICAM-1 Monoclonal Antibody (MEM-111)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| Flow Cytometry (Flow) | 0.5–4 µg/mL | 6 publications |
| ELISA | Assay-dependent | - |
| Miscellaneous PubMed | - | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Human, Rat |
| Published Species | Cat, Human, Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-111 |
| Immunogen | Burkitt's lymphoma cell line Raji |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1072566 |
Additional Formats
Product Specific Information
This antibody reacts with an extracellular epitope of CD54 (ICAM-1), an 85–110 kDa type I transmembrane glycoprotein that serves as a receptor for rhinovirus. Expression of CD54 is upregulated upon activation and is found on activated endothelial cells, T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes, and dendritic cells.
Western Blot: non-reducing conditions.
Immunohistochemistry (paraffin sections): positive tissue includes thymus and RE cells.
Target Information
ICAM-1 (CD54) is an 85–110 kDa single-chain type I integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region, and a cytoplasmic domain. It has seven potential N-linked glycosylation sites and shares sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102).
ICAM-1 binds integrins CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1), and serves as a receptor for rhinovirus. It is expressed by activated endothelial cells, epithelial cells, fibroblasts, chondrocytes, B and T lymphocytes, monocytes, macrophages, dendritic cells, and neutrophils, with levels increasing during inflammation. ICAM-1 is also found in certain carcinoma and melanoma cells. Soluble ICAM-1 is detectable in plasma and elevated in inflammatory syndromes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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