Thermo Fisher Scientific CD45RB Monoclonal Antibody (MEM-55)
CD45RB 단백질을 인식하는 Mouse IgG1 단클론 항체로, 인간 및 비인간 영장류에 반응합니다. WB, IHC, Flow Cytometry, IP 등에 사용 가능하며, Protein A로 정제된 액상 형태입니다. 세포 표면 CD45RB isoform 검출에 적합합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL | - |
| Flow Cytometry (Flow) | 2 µg/mL | 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-55 |
| Immunogen | Human thymocytes and T lymphocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1072470 |
Additional Formats
Product Specific Information
This antibody recognizes a sialidase-sensitive extracellular epitope of CD45RB, a 180–240 kDa single chain type I membrane glycoprotein, variant of CD45 (CD45RB isoform).
CD45RB is expressed on subsets of T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes, and dendritic cells.
Immunohistochemistry (Paraffin): No pre-treatment of tissue sections is needed.
Target Information
CD45RB is a receptor-type protein tyrosine phosphatase, part of the CD45 glycoprotein family.
CD45 is essential in lymphocyte development and antigen signaling, acting as a regulator of Src-family kinases. It promotes cell survival via integrin-mediated signaling and participates in DNA fragmentation during apoptosis.
CD45 isoforms differ in extracellular domains but share identical transmembrane and cytoplasmic domains. Expression varies by cell type and physiological state.
CD45RB is found in microglia and inflammatory cells, and is expressed on cells of the human hematopoietic lineage except mature red cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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