Thermo Fisher Scientific CD45RA Monoclonal Antibody (MEM-56)
CD45RA 단백질의 세포외 에피토프를 인식하는 Mouse IgG2b 단클론 항체로, 인간 및 다양한 영장류 종에 반응합니다. WB, IHC, Flow Cytometry, IP 등 다양한 응용에 적합하며, PBS 버퍼 내 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL | - |
| Flow Cytometry (Flow) | 0.3–4 µg/mL | View 22 publications |
| Immunoprecipitation (IP) | Assay-dependent | - |
| Miscellaneous PubMed (Misc) | - | View 17 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Baboon, Human, Mouse, Non-human primate, Rhesus monkey |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-56 |
| Immunogen | Human thymocytes and T lymphocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1072449 |
Available Formats
Product Specific Information
This antibody reacts with an extracellular epitope of CD45RA, a 205–220 kDa single-chain type I glycoprotein, variant of CD45 (CD45RA isoform).
CD45RA is expressed on most B lymphocytes, resting and native T lymphocytes, medullar thymocytes, and monocytes.
This antibody has been successfully used in Mass Cytometry (CyTof).
Immunohistochemistry (Paraffin): No pre-treatment of tissue sections is needed.
Target Information
CD45RA is an isoform of the CD45 complex and exhibits restricted expression among lymphoid cell subtypes.
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase expressed in all nucleated hematopoietic cells, constituting about 10% of lymphocyte surface proteins.
CD45 glycoprotein plays a key role in lymphocyte development and antigen signaling by regulating Src-family kinases.
The CD45 isoforms differ in extracellular domains due to alternative splicing but share identical transmembrane and cytoplasmic domains.
These isoforms vary in membrane localization and expression depending on cell type and physiological state.
CD45 is essential for immunoreceptor signaling, cell survival via integrin-mediated pathways, and DNA fragmentation during apoptosis.
It is expressed in cells of the human hematopoietic lineage (except mature red cells) and is absent in differentiated non-hematopoietic tissues.
Dysfunction of CD45 is associated with severe combined immunodeficiency and Hepatitis C.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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