Thermo Fisher Scientific alpha Synuclein Monoclonal Antibody (3F8), PerCP
Alpha Synuclein 단백질을 검출하는 3F8 클론의 PerCP 결합 단일클론 항체. 인간, 마우스, 랫트 반응성. WB, IHC, ICC, ELISA 등 다양한 응용 가능. Protein G 정제, 1 mg/mL 농도, 4°C 보관.
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Thermo Fisher Scientific Alpha Synuclein Monoclonal Antibody (3F8), PerCP
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| ELISA | 1:1,000 |
| Dot Blot (DB) | 1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3F8 |
| Immunogen | Mouse alpha synuclein aggregate |
| Conjugate | PerCP |
| Excitation / Emission Max | 482 / 675 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932299 |
Available Formats
Product Specific Information
- 1:1,000 dilution of MA5-45845 detects Alpha Synuclein in 15 µg of human brain cell lysate by ECL immunoblot using goat anti-mouse IgG:HRP as secondary antibody.
- Binds within the 101–140 aa region of human alpha synuclein, confirmed by WB and ELISA with corresponding peptides.
- Detects approximately 14 kDa band corresponding to Alpha Synuclein.
- Does not detect truncated alpha Synuclein (aa 1–114).
Target Information
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play roles in regulating synaptic transmission and membrane trafficking.
Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting involvement in signaling pathways.
Defects in the SNCA gene (encoding alpha-synuclein) are linked to Parkinson’s disease pathogenesis.
Alpha-synuclein peptides are major components of amyloid plaques in Alzheimer’s disease.
Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Diseases associated with SNCA include Parkinson Disease 1 (Autosomal Dominant) and Dementia, Lewy Body.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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