Thermo Fisher Scientific Phospho-DYRK1A/DYRK1B (Tyr321, Tyr273) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:3,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human DYRK1A(Accession Q13627), corresponding to amino acid residues around phosphorylated Tyr321. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DYRK1A/DYRK1B,uniProtId:Q13627-1,ncbiNodeId:9606,antigenRange:321,antigenLength:763,antigenImageFileName:PA5-105874_DYRK1ADYRK1B_Q13627-1_Rabbit.svg,antigenImageFileNamePDP:PA5-105874_DYRK1ADYRK1B_Q13627-1_Rabbit_PDP.jpeg,sortOrder:1},{targetFamily:DYRK1A/DYRK1B,uniProtId:Q9Y463-1,ncbiNodeId:9606,antigenRange:273|321,antigenLength:629,antigenImageFileName:PA5-105874_DYRK1ADYRK1B_Q9Y463-1_Rabbit.svg,antigenImageFileNamePDP:PA5-105874_DYRK1ADYRK1B_Q9Y463-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2817273

Product Specific Information

Antibody detects endogenous levels of DYRK1A/B only when phosphorylated at Tyr321/273.

Target Information

DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family and is thought to be involved in neuronal differentiation, neurodegenerative diseases, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. DYRK1A phosphorylates several transcription factors such as p53, leading to inhibition of embryonic neuronal cell proliferation. DYRK1A associates with multiple proteins, including SPRED1 and SPRED2; this association appears to inhibit the phosphorylation activity of DYRK1A. Recent evidence also suggests that DYRK1A may be involved in the replication of HIV-1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.