Thermo Fisher Scientific Phospho-DYRK2/DYRK4 (Tyr382, Tyr264) Polyclonal Antibody
DYRK2/DYRK4의 인산화된 형태(Tyr382, Tyr264)를 인식하는 토끼 폴리클로날 항체. Western blot과 IHC(P)에서 검증됨. 인산화 의존적 검출에 적합하며, 세포 내 신호전달 및 스트레스 반응 연구에 활용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DYRK2 (Accession Q92630), corresponding to amino acid residues around phosphorylated Tyr382. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817274 |
Product Specific Information
This antibody detects endogenous levels of DYRK2/4 only when phosphorylated at Y382/Y264.
Target Information
DYRK2 belongs to the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family, involved in cellular proliferation and apoptosis. Under normal conditions, nuclear DYRK2 is ubiquitinated by MDM2, leading to degradation. Upon genotoxic stress, ATM phosphorylates DYRK2, causing dissociation from MDM2 and phosphorylation of p53, thereby inducing apoptosis. DYRK2 may also act as a scaffold facilitating E3 ubiquitin ligase assembly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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