Thermo Fisher Scientific Phospho-FGFR2 (Tyr769) Polyclonal Antibody
FGFR2의 Tyr769 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin)에 적합하며, 1 mg/mL 농도의 액상형 제품. 세포 신호전달 및 암 연구용으로 최적화된 항체.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
- Publications: View 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: View publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FGFR2 (Accession P21802), corresponding to amino acid residues around phosphorylated Tyr769 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817279 |
Product Specific Information
Antibody detects endogenous levels of FGFR2 only when phosphorylated at Tyr769.
Target Information
FGFR2 is a member of the FGFR family of receptor tyrosine kinases. This family regulates key cellular functions such as angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair.
FGFR family members are implicated in various diseases, including cancer, rheumatoid arthritis, and diabetic retinopathy.
Mutations in FGFR2 are associated with several syndromes such as Crouzon, Pfeiffer, Craniosynostosis, Apert, Jackson-Weiss, Beare-Stevenson cutis gyrata, Saethre-Chotzen, and syndromic craniosynostosis.
Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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