Thermo Fisher Scientific Phospho-CSK (Tyr304) Polyclonal Antibody
CSK 단백질의 Tyr304 인산화를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 고순도 정제 및 안정한 글리세롤 보존 용액 형태로 제공.
- 카탈로그번호
- PA5105871
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry / Immunofluorescence (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CSK (Accession P41240), corresponding to amino acid residues around phosphorylated Tyr304 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817270 |
Product Specific Information
This antibody detects endogenous levels of CSK only when phosphorylated at Tyr304.
Target Information
CSK (C-terminal Src kinase) is a tyrosine kinase that downregulates SRC oncoprotein activity by phosphorylating its carboxy terminus. Disruption of this phosphorylation is associated with cell transformation by SRC, suggesting that CSK may function as an antioncogene. CSK plays a crucial role in regulating cell growth, differentiation, migration, and immune responses. It phosphorylates tyrosine residues in the C-terminal tails of Src-family kinases such as LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is ubiquitously expressed as a ~50 kDa cytosolic protein, with a fraction localized to lipid rafts through interaction with PAG (Csk-binding protein).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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