Thermo Fisher Scientific GTF3C3 Polyclonal Antibody
GTF3C3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P)에서 검증됨. 인간, 생쥐, 랫트 반응성. 항원 친화 크로마토그래피로 정제되어 고순도(>95%) 확보. 연구용으로만 사용.
- 카탈로그번호
- PA536290
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 100–150 of human TFIIIC102 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553456 |
Product Specific Information
- Detects endogenous protein at a molecular weight of 101 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
RNA polymerase (Pol) III synthesizes tRNA, 5S rRNA, 7SL RNA, and U6 snRNA, and is overexpressed in many transformed cell lines and tumors. Cells require high levels of Pol III-transcribed RNA for rapid growth, which involves TFIIIB and TFIIIC2 transcription factor complexes.
The TFIIIC2 complex consists of five subunits: TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90, and TFIIIC63, all of which are overexpressed in malignant cells such as ovarian carcinomas. TFIIIC2 recruits RNA Pol III and TFIIIB to promoter elements and may play a key role in tumor cell deregulation.
TFIIIB includes TBP, BRF1, and TFIIIB subunits, whose expression is also upregulated in transformed cells. In many carcinomas, tumor suppressors RB and p53 are inactivated, reducing their ability to bind and inhibit TFIIIB function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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