Thermo Fisher Scientific MEK6 Polyclonal Antibody
Rabbit polyclonal antibody against MEK6 (MAP2K6), validated for WB, ICC/IF, and Flow Cytometry. High specificity to human and mouse MAP2K6. Supplied unconjugated in PBS with BSA and glycerol. Ideal for research use in MAP kinase signaling studies.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.75–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
| Flow Cytometry (Flow) | 5 µg per 10^6 cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptides corresponding to Human MAP2K6 (aa 5–23, 317–334) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS (pH 7.4) with 0.1% BSA and 30% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2633254 |
Product Specific Information
These polyclonal antibodies are of rabbit origin and developed by immunizing animals with specific proteins or peptides. The antibody is purified by affinity chromatography and tested for functionality in relevant research applications.
Developed for Research Use Only and classified as non-hazardous and non-infectious.
This antibody is predicted to react with Monkey, Pig, and Horse.
Target Information
MKK6 (MEK6, MAP2K6) is a member of the dual specificity protein kinase family, functioning as a mitogen-activated protein (MAP) kinase kinase. MAP kinases (ERKs) serve as integration points for multiple biochemical signals.
MKK6 phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress.
It plays a key role in p38 MAP kinase–mediated signal transduction, involved in processes such as stress-induced cell cycle arrest, transcription activation, and apoptosis.
Tissue Specificity:
- Isoform 2: Expressed only in skeletal muscle
- Isoform 1: Found in skeletal muscle, heart, and to a lesser extent in liver and pancreas
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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