Thermo Fisher Scientific CD27 Recombinant Armenian Hamster Monoclonal Antibody (LG.3A10)

Applications

Product Specifications

Product Specific Information

This antibody is specific for mouse CD27, which, as in the human system, is largely restricted to cells of the T cell lineage, and is expressed on the great majority of both αβ and γδ T lymphocytes, and thymocytes.

Target Information

CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. Members of the TNF superfamily regulate cell proliferation and death. Expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. CD27 is expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells, and a subpopulation of B cells. Activation of T cells via the TCR-CD3 complex upregulates CD27 expression and promotes release of its soluble 28–32 kDa form (sCD27), found in plasma, urine, or spinal fluid. Soluble CD27 serves as an important prognostic marker in acute and chronic B cell malignancies. RgpA, a cysteine proteinase, degrades CD27 and counteracts T cell activation mediated by CD27-CD70 interaction. CD27-binding protein (SIVA), a proapoptotic protein, binds to this receptor and is implicated in apoptosis induced by CD27. Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.