Thermo Fisher Scientific CD23 Recombinant Mouse Monoclonal Antibody (CAT-13.9C1)
CD23 단백질을 인식하는 마우스 유래 재조합 단클론 항체로, B 세포 분화 및 IgE 조절 연구에 적합합니다. HEK293 세포에서 발현되며 Protein A로 정제되었습니다. PBS 완충액에 0.02% ProClin 300이 포함되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | CAT-13.9C1 |
| Immunogen | This antibody was raised by immunising mice with an EBV-transformed human B cell line from a patient with MHC class II deficiency re-expressing class II antigens. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody recognises CD23, a low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. CD23 plays essential roles in regulating IgE production and in the differentiation of B-cells.
Target Information
CD23 is a 45 kDa glycoprotein expressed on a subset of freshly isolated peripheral blood and tonsil B cells, and strongly expressed on EBV-transformed B lymphoblasts. It is identical to the low-affinity IgE receptor found on B cells. CD23 expression has been detected in neoplastic cells from B cell chronic lymphocytic leukemia and some centroblastic/centrocytic lymphomas. Functionally, CD23 is involved in B cell growth, differentiation, and IgE production. The soluble form of CD23 acts as a potent mitogenic factor. Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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