Thermo Fisher Scientific Integrase interactor 1 (INI-1)/SNF5/SMARCB1 Monoclonal Antibody (SMARCB1/3984)
Thermo Fisher Scientific의 SMARCB1/3984 단클론 항체는 인간 SMARCB1 단백질(aa 65-184)을 면역원으로 제작되었습니다. IHC(P), IHC(PFA), Peptide Array에 사용 가능하며, 단백질 A/G로 정제된 액상 항체입니다. 보존제 없이 PBS(pH 7.4)에 용해되어 있으며, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | - |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL | - |
| Peptide Array (Array) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SMARCB1/3984 |
| Immunogen | Recombinant fragment (around aa 65–184) of human SMARCB1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF2alpha) and Brg-1 (also designated SNF2beta) are the ATPase subunits of the mammalian SWI-SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3), and BAF170 are thought to comprise the functional core of the SWI-SNF complex. Addition of Ini1, BAF155, and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits are thought to play regulatory roles. hSNF2L and hSNF2H both appear to be homologs of Drosophila ISWI, a Brm-related ATPase that is present in chromatin remodeling complexes other than SWI/SNF, including the NURF (nucleosome remodeling factor).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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