Thermo Fisher Scientific Integrase interactor 1 (INI-1)/SNF5/SMARCB1 Monoclonal Antibody (rSMARCB1/4588)
Thermo Fisher Scientific의 INI-1/SNF5/SMARCB1 단클론 항체는 인간 및 마우스 시료에서 SWI-SNF 복합체 연구용으로 적합합니다. IHC(P) 및 IHC(PFA) 실험에 사용 가능하며, 단백질 A/G로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rSMARCB1/4588 |
| Immunogen | Recombinant fragment of mouse BAF47 protein (around aa257–359) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner.
Brm (also designated SNF2alpha) and Brg-1 (also designated SNF2beta) are the ATPase subunits of the mammalian SWI-SNF complex.
Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3), and BAF170 comprise the functional core of the SWI-SNF complex.
Addition of Ini1, BAF155, and BAF170 to Brg-1 increases remodeling activity, while other complex subunits play regulatory roles.
hSNF2L and hSNF2H are homologs of Drosophila ISWI, a Brm-related ATPase present in chromatin remodeling complexes other than SWI/SNF, including the NURF (nucleosome remodeling factor).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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