Thermo Fisher Scientific pro-Brain Natriuretic Peptide Monoclonal Antibody (15F11)
인간 proBNP를 인식하는 Mouse IgG2b 단클론 항체로, Western blot 및 ELISA에 사용 가능. 합성 펩타이드(13-27 aa) 면역원 사용. 단백질 A 정제, 5.8 mg/mL 농도의 액상 형태. 4°C 보관, 연구용 전용 시약.
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Applications
Western Blot (WB)
- Tested Dilution: Assay-dependent
ELISA
- Tested Dilution: Assay-dependent
Miscellaneous (PubMed)
- Publications: 1 available
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 15F11 |
| Immunogen | Synthetic peptide corresponding to residues E(13)TSGLQEQRNHLQGK(27) of human proBNP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5.8 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_560694 |
Product Specific Information
MA1-20626 detects proBNP in human samples.
Target Information
In cardiac tissue, brain natriuretic peptide (BNP) is synthesized as a 134 amino acid precursor (prepro-BNP), which is cleaved by proteases to form a 26 aa signal peptide and a 108 aa pro-BNP. Proteolytic digestion of pro-BNP results in the formation of a 76 aa amino-terminal NT-proBNP and a biologically active 32 aa BNP hormone molecule. Both proBNP and NT-proBNP circulate in human plasma and have been proposed as markers for early diagnosis of left ventricular dysfunction as well as prognostic markers for possible cardiac complications in patients with heart failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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