Thermo Fisher Scientific LOXL2 Monoclonal Antibody (OTI8B2), TrueMAB
Human LOXL2 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI8B2). IHC(P)에서 검증된 TrueMAB 형식 제품으로, 고순도 친화 크로마토그래피 정제 및 동결건조 형태 제공. 연구용으로만 사용 가능.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8B2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 152–450 of human LOXL2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The LOXL2 gene encodes a member of the lysyl oxidase family, which plays a crucial role in connective tissue biogenesis. This enzyme is a copper-dependent amine oxidase that catalyzes the initial step in collagen and elastin crosslink formation.
The conserved C-terminal region is essential for amine oxidase activity, while the variable N-terminal region may contribute to functions such as developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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