Thermo Fisher Scientific FERMT3 Monoclonal Antibody (OTI2G2), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The three KINDLINs constitute a novel family of focal adhesion proteins localized to integrin adhesion sites.
Each KINDLIN protein contains a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain.
KINDLIN1 and KINDLIN2 are widely expressed and play essential roles in integrin-mediated adhesion and spreading.
In contrast, KINDLIN3 expression is restricted to hematopoietic cells, particularly abundant in megakaryocytes and platelets.
Reports indicate transcriptional misregulation of KINDLINs in various cancers.
KINDLIN3 is essential for platelet integrin activation and subsequent outside-in signaling, suggesting its potential as a therapeutic target for modulating integrin activation in platelets and leukocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.