Thermo Fisher Scientific FERMT3 Monoclonal Antibody (OTI2H10), TrueMAB
Human FERMT3 단백질(Kindlin 3)을 인식하는 Mouse IgG1 단클론 항체로, WB 및 IHC(P) 실험에 적합합니다. 무보존제, 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능합니다. 혈소판 및 백혈구 인테그린 활성 연구에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 259–528 of human FERMT3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain an antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The three KINDLINs (Kindlin-1, Kindlin-2, Kindlin-3) are focal adhesion proteins localized to integrin adhesion sites. Each contains a FERM domain interrupted by a pleckstrin homology (PH) domain.
While KINDLIN1 and KINDLIN2 are widely expressed, KINDLIN3 is restricted to hematopoietic cells and is abundant in megakaryocytes and platelets. KINDLIN3 is essential for platelet integrin activation and outside-in signaling, making it a potential target for therapies aimed at modulating integrin activation in platelets and leukocytes.
Transcriptional misregulation of KINDLINs has been reported in various cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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