Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI7B4), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Cell-mediated immune responses are initiated by T lymphocytes stimulated by antigen-presenting cells (APCs). Activated T cells express PD-1 (also known as PDCD-1), a receptor that mediates inhibitory signals upon binding its ligands PDL-1 or PDL-2. These interactions suppress immune activation in the absence of danger signals. PD-1 deficiency leads to hyperactivated immune responses and autoimmune conditions. Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.