Thermo Fisher Scientific beta Synuclein Polyclonal Antibody
Human 및 Rat 시료에 반응하는 beta Synuclein 폴리클로날 항체. 면역조직화학(IHC)에 적합하며, 합성 펩타이드(108–125 aa)를 면역원으로 사용. 동결건조 형태로 제공되며, 보존제를 포함하지 않음. -20°C 보관, 반복적인 동결/해동 회피 필요.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:3000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues I(108) E P L M E P E G S Y E D P P Q E(125) of human beta synuclein protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1070673 |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
After reconstitution, keep aliquots at -20°C for higher stability, and at 4°C with an appropriate antibacterial agent.
Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
Target Information
Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals.
In vertebrates, they are encoded by three different genes. Synucleins are implicated in major diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and breast cancer.
- In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid.
- In PD, alpha synuclein accumulates in Lewy bodies, and an allele of alpha synuclein is linked to familial PD.
- In breast cancer, increased expression of gamma synuclein correlates with disease progression.
Synucleins appear to be involved in membrane plasticity in the developing song control system of songbirds.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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