Thermo Fisher Scientific beta Synuclein Polyclonal Antibody
Human 및 Rat 시료에 반응하는 beta Synuclein 폴리클로날 항체. 면역조직화학(IHC-F) 검증 완료. 합성 펩타이드 면역원 사용. 동결건조 형태로 제공되며 -20°C 보관 권장. 연구용으로만 사용 가능.
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Applications
Immunohistochemistry (Frozen) (IHC (F))
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues I(108)EPLMEPEG SYEDPPQE(125) of human beta synuclein protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1070672 |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution, keep aliquots at -20°C for higher stability, or at 4°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
Target Information
The synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates, they are encoded by three different genes. Synucleins have been implicated in major diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and breast cancer.
- In AD, a peptide derived from alpha synuclein forms a component of plaque amyloid.
- In PD, alpha synuclein accumulates in Lewy bodies, and certain alleles are linked to familial PD.
- In breast cancer, increased expression of gamma synuclein correlates with disease progression.
- Synucleins may also play a role in membrane plasticity in the developing song control system of songbirds.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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