Thermo Fisher Scientific beta Synuclein Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Immunohistochemistry (Frozen) (IHC (F))

• Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution, keep aliquots at -20 °C for higher stability, or at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.

Target Information

The synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates, they are encoded by three different genes. Synucleins have been implicated in major diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and breast cancer.

• In AD, a peptide derived from alpha synuclein forms part of plaque amyloid.
• In PD, alpha synuclein accumulates in Lewy bodies, and certain alleles are linked to familial PD.
• In breast cancer, increased expression of gamma synuclein correlates with disease progression.
  Synucleins may also be involved in membrane plasticity in the developing song control system of songbirds.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.