Thermo Fisher Scientific alpha Synuclein Polyclonal Antibody
Human 및 Rat 시료에 반응하는 sheep 유래 polyclonal alpha-synuclein 항체. IHC(P) 실험에 1 µg/mL 농도로 사용 가능. Lyophilized 형태로 제공되며 PBS buffer에 sodium azide 포함. Parkinson 및 Alzheimer 연구에 적합.
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- PA118258
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested at 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues P(108) Q E G I L E D M P V D P C(120) of human alpha-synuclein protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1070238 |
Product Specific Information
Reconstitute in 50 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution, store aliquots at -20°C for higher stability, or at 4°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
Target Information
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting involvement in signaling pathways.
Defects in the SNCA gene, encoding alpha-synuclein, are implicated in the pathogenesis of Parkinson’s disease. Alpha-synuclein peptides are also major components of amyloid plaques in Alzheimer’s disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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