Thermo Fisher Scientific Carbonic Anhydrase IX Recombinant Rabbit Monoclonal Antibody (JJ088-9)
인간 Carbonic Anhydrase IX 단백질을 인식하는 재조합 토끼 단클론 항체입니다. Western blot과 IHC(P)에서 높은 특이성과 재현성을 제공합니다. 단백질 A로 정제된 액상형 제품으로, 4°C 단기 보관 및 -20°C 장기 보관이 가능합니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JJ088-9 |
| Immunogen | Recombinant protein within Human Carbonic anhydrase 9 aa 184–276 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809734 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal clones for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
Carbonic anhydrase (CA) is an enzyme that catalyzes the rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions.
CA IX is a hypoxia-inducible gene product stabilized and localized within the membrane, serving as a reliable histochemical marker of hypoxia.
Carbonic anhydrases regulate pH by controlling hydrogen ion flux, and inhibition of CA IX can increase cell death under hypoxic conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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