Thermo Fisher Scientific CD44 Polyclonal Antibody
CD44 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 및 Mouse 시료에 반응합니다. Western blot, IHC, ELISA에 적합하며, 세포막 단백질 CD44 검출에 사용됩니다. 고순도 Affinity Chromatography 정제, 50% glycerol 함유 PBS buffer에 보관됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 20–178 of CD44 (NP_0006013) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.91 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805460 |
Product Specific Information
Immunogen sequence:
AQIDLNITCR FAGVFHVEKN GRYSISRTEA ADLCKAFNST LPTMAQMEKA LSIGFETCRY GFIEGHVVIP RIHPNSICAA NNTGVYILTS NTSQYDTYCF NASAPPEEDC TSVTDLPNAF DGPITITIVN RDGTRYVQKG EYRTNPEDIY PSNPTDDDV
Positive Samples: MCF7, HeLa, Raji, A-549, U-251MG, Mouse liver, Mouse spleen
Cellular Location: Cell membrane, Single-pass type I membrane protein
Target Information
CD44 is a 100 kDa type I transmembrane glycoprotein expressed on human leukocytes, brain white matter, and epithelial cells of the intestine and breast. It serves as a receptor for hyaluronic acid (HA) and plays key roles in cell-cell interaction, adhesion, and migration. CD44 is involved in lymphocyte activation, recirculation, and homing. Its expression is often upregulated in carcinomas and may be linked to metastatic potential. Multiple isoforms exist due to alternative splicing, contributing to structural and functional diversity. CD44 dysfunction is associated with diseases such as superficial keratitis and lichen sclerosus, and it may be related to tumor metastasis formation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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