Thermo Fisher Scientific MTM1 Polyclonal Antibody
MTM1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 ELISA에 적합합니다. Mouse와 Rat 시료에 반응하며, 고순도의 Affinity Chromatography 정제 항체입니다. PBS 버퍼에 50% 글리세롤이 포함되어 있으며 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 484–603 of human MTM1 (NP_000243.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.14 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805464 |
Product Specific Information
Immunogen sequence:
SARERQKVTE RTVSLWSLIN SNKEKFKNPF YTKEINRVLY PVASMRHLEL WVNYYIRWNP RIKQQQPNPV EQRYMELLAL RDEYIKRLEE LQLANSAKLS DPPTSPSSPS QMMPHVQTHF
Positive Samples: Mouse thymus
Cellular Location: Cell membrane, Cell projection, Cytoplasm, Late endosome, Peripheral membrane protein, filopodium, ruffle
Target Information
Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The related protein hMTMR2 is mutated in a recessive form of Charcot-Marie-Tooth neuropathy. Myotubularin is a lipid phosphatase that acts on phosphatidylinositol 3-monophosphate, regulating the phosphatidylinositol 3-kinase (PI3K) pathway and membrane trafficking. Wild-type myotubularin dephosphorylates PI 3-P and PI 4-P in vitro, decreasing PI 3-P levels by down-regulating PI3K activity and facilitating PI 3-P degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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