Thermo Fisher Scientific CD46 Polyclonal Antibody
Thermo Fisher Scientific의 CD46 폴리클로날 항체는 인간 CD46 단백질을 표적으로 하는 연구용 항체입니다. WB 및 ELISA에 적합하며, 고순도 친화 크로마토그래피로 정제되었습니다. 세포막 및 소포 내 CD46 단백질 검출에 유용합니다. -20°C에서 안정적으로 보관 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 40–320 of human CD46 (NP_7225481) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.73 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805462 |
Product Specific Information
Immunogen sequence:
TFEAMELIGK PKPYYEIGER VDYKCKKGYF YIPPLATHTI CDRNHTWLPV SDDACYRETC PYIRDPLNGQ AVPANGTYEF GYQMHFICNE GYYLIGEEIL YCELKGSVAI WSGKPPICEK VLCTPPPKIK NGKHTFSEVE VFEYLDAVTY SCDPAPGPDP FSLIGESTIY CGDNSVWSRA APECKVVKCR FPVVENGKQI SGFGKKFYYK ATVMFECDKG FYLDGSDTIV CDSNSTWDPP VPKCLKVSTS STTKSPASSA SGPRPTYKPP VSNYPGYPKP E
Positive Samples: HT-29
Cellular Location: Cytoplasmic vesicle, Single-pass type I membrane protein, acrosome inner membrane, secretory vesicle
Target Information
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments. It regulates T cell-induced inflammatory responses, either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alters T lymphocyte polarization toward antigen-presenting or target cells, inhibiting lymphocyte function. CD46 protects placental tissue and is expressed on the inner acrosomal membrane of spermatozoa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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