Thermo Fisher Scientific IRS1 Polyclonal Antibody
Thermo Fisher Scientific의 IRS1 Polyclonal Antibody는 인간 IRS1 단백질을 인식하는 Rabbit IgG 항체로, Western blot과 IHC에 적합합니다. 고순도 항원 친화 크로마토그래피로 정제되었으며, 안정적인 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA529667
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IRS1 Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:20,000
- Publications: 참고 문헌 보기
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
- Publications: 참고 문헌 보기
Miscellaneous PubMed (Misc)
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 882–1178 of Human IRS1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547142 |
Product Specific Information
- Recommended positive controls: A431, MDA-MB-231
- Predicted reactivity: Pig (85%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation by insulin, insulin-like growth factor 1 (IGF-1), and interleukin 4 (IL-4).
IRS-1 undergoes phosphorylation on serine, threonine, and tyrosine residues in various tissues. Casein kinase II mediates part of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo.
Thr 502 is the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site.
IRS-1 contains three putative binding sites for 14-3-3 proteins (Ser 270, Ser 374, Ser 641), with the motif around Ser 270 located in the phosphotyrosine-binding domain responsible for insulin receptor interaction.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-29667_IRS1_P35568-1_Rabbit.svg, PA5-29667_IRS1_P35568-1_Rabbit_PDP.jpeg)
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