Thermo Fisher Scientific PTPN22 Polyclonal Antibody
PTPN22 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 실험에 적합합니다. Human, Mouse, Rat에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 동결건조 형태로 제공되며, 재구성 시 500 µg/mL 농도로 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived mouse PTPN22 recombinant protein (Position: M1–Q309) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 4 mg trehalose |
| Contains | 0.05 mg sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2747011 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
The protein tyrosine phosphatase PTPN22 (also known as PTP22, LYP, PEP, formerly PTPN8) is a genetic variant associated with increased risk of autoimmune diseases such as type 1 diabetes and rheumatoid arthritis.
A missense SNP in PTPN22 encodes a hematopoietic-specific phosphatase (Lyp). The risk allele occurs in approximately 17% of Caucasian individuals in the general population and about 28% among those with rheumatoid arthritis.
This variant is believed to disrupt the P1 proline-rich motif important for interaction with the SH3 domain of CSK (cytoplasmic tyrosine kinase), potentially altering the normal regulatory function of these proteins in T cell activation.
The CSK–PTPN22 interaction is highly specific, suggesting that PTPN22 may act as an effector and/or regulator of CSK in T cells and other hematopoietic cells.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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