Thermo Fisher Scientific PTP1B Polyclonal Antibody
PTP1B 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, Flow Cytometry 등 다양한 응용에 사용 가능. 고순도 항원 친화 크로마토그래피 정제. 동결건조 형태로 제공되며 -20°C 보관. 연구용으로만 사용.
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Thermo Fisher Scientific PTP1B Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–5 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | 2–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1 µg/mL |
| Flow Cytometry (Flow) | 1–3 µg/1×10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to N-terminus of human PTP1B (4–30 aa: EKEFEQIDKSGSWAAIYQDIRHEASDF) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 4 mg trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2747009 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
PTP1B (PTPN1) is a tyrosine-protein phosphatase that regulates the endoplasmic reticulum unfolded protein response by mediating dephosphorylation of EIF2AK3/PERK, inactivating its kinase activity. It participates in CKII- and p60c-src-induced signaling cascades, regulates EFNA5-EPHA3 signaling for cell reorganization and repulsion, and modulates hepatocyte growth factor receptor (MET) signaling through dephosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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