Thermo Fisher Scientific COPII Polyclonal Antibody
Thermo Fisher Scientific COPII Polyclonal Antibody는 인간, 생쥐, 랫트에서 COPII 단백질을 검출하는 토끼 IgG 항체입니다. Western blot 및 ICC/IF에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS+BSA 용액에 보관되며 -20°C에서 안정적입니다.
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- PA1069A
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | View 3 publications |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:10–1:200 | View 10 publications |
| Immunoprecipitation (IP) | - | View 1 publication |
| Functional Assay (Functional) | - | View 1 publication |
| Immunomicroscopy (IM) | - | View 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Fruit fly, Hamster, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues M(1) T T Y L E F I Q Q N E E R D G V R (18) C of rat COPII |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2301581 |
Product Specific Information
PA1-069A detects coatomer-protein II (COPII) from rat, mouse, and human cells.
It has been successfully used in Western blot and ICC/IF procedures.
By Western blot, this antibody detects an ~85 kDa protein representing COPII from PC-12 cell extract.
The immunogen is a synthetic peptide corresponding to residues M(1) T T Y L E F I Q Q N E E R D G V R (18) C of rat COPII, conserved across human, mouse, and rat.
PA1-069A immunizing peptide (Cat. # PEP-127) is available for use in neutralization and control experiments.
Target Information
Coatomer proteins regulate transport between the endoplasmic reticulum (ER) and the Golgi complex, as well as intra-Golgi transport.
There are two coatomer-protein mechanisms, COPI and COPII, which are molecularly distinct.
- COPI: Composed of seven subunits (α-, β-, β’-, γ-, δ-, ε-, and ζ-COP) forming the coatomer complex. Its assembly onto non-clathrin vesicles is regulated by ADP-ribosylation factor (ARF) and facilitates retrograde transport from ER to Golgi.
- COPII: Facilitates anterograde transport between ER and Golgi. It is independently and selectively recruited to the ER and consists of Sar1p, Sec23p–Sec24p, and Sec13p–Sec31p complexes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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