Thermo Fisher Scientific MINT3 Polyclonal Antibody
Rabbit polyclonal antibody against MINT3 for WB, IHC, and ICC applications. Reacts with human, mouse, and rat samples. Validated in multiple publications. Supplied as liquid, 1 mg/mL, stored at -20°C. For research use only.
- 카탈로그번호
- PA1072
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific MINT3 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | View 3 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | View 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues M(1)EFLPEPQHPPGPPTMDLE(19) of rat Mint3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2057069 |
Product Specific Information
PA1-072 detects munc-18 interacting protein 3 (Mint3) from mouse cells and rat brain samples.
It has been successfully used in Western blot procedures, detecting an ~86 kDa protein representing Mint3 from AtT20 cell extract and rat brain samples.
The immunogen is a synthetic peptide corresponding to residues M(1)EFLPEPQHPPGPPTMDLE(19) of rat Mint3.
The immunizing peptide (Cat. # PEP-135) is available for use in neutralization and control experiments.
Target Information
The munc-18 interacting protein (Mint) family comprises conserved adaptor proteins involved in membrane transport and organization.
In mammals, three isoforms exist: Mint1, Mint2, and Mint3. While the amino-terminal region shows little sequence conservation, the carboxy-terminal region is highly conserved and contains a phosphotyrosine-binding (PTB) domain and a PSD-95/DLG-A/ZO-1 (PDZ) domain, both serving as protein interaction modules.
- Mint1 and Mint2: Expressed mainly in the brain; bind to Munc18, a key component of synaptic vesicle fusion.
- Mint3: Ubiquitously expressed, lowest in brain and testis; does not interact with Munc18.
- Functional relevance: Mint3 interacts with the Alzheimer’s disease-related amyloid precursor protein (APP) through PTB and PDZ domains, potentially linking APP to transport machinery and influencing its metabolism.
Abnormal APP metabolism is implicated in early-onset Alzheimer’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.