Thermo Fisher Scientific LMAN1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

PA1-074 detects ERGIC-53 in rat, mouse, and human samples.
This antibody has been successfully used in Western blot and immunofluorescence (ICC/IF) procedures.
By Western blot, it detects a ~57.5 kDa protein representing ERGIC-53 in rat brain samples.

The immunogen is a synthetic peptide corresponding to residues F(159) D S F D N D G K K N N P A I(173) of rat ERGIC-53, conserved in mouse and human.
The immunizing peptide (Cat. # PEP-277) is available for use in neutralization and control experiments.

Target Information

The LMAN1 protein is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi apparatus, recycling between these compartments.
It functions as a mannose-specific lectin and belongs to a family of plant lectin homologs in the secretory pathway of animal cells.
Mutations in this gene are associated with a coagulation defect, specifically combined factor V-factor VIII deficiency, a rare autosomal recessive disorder characterized by reduced levels of both coagulation factors V and VIII.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.