Thermo Fisher Scientific HIC1 Monoclonal Antibody (3B2)
HIC1 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단클론 항체. Western blot 및 ELISA에 사용 가능하며, 종 특이성은 인간. 정제된 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B2 |
| Immunogen | HIC1 (NP_006488.2, 627–705 a.a.) full-length recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
PEGVFAVARL TAEQLSLKQQ DKAAAAELLA QTTHFLHDPK VALESLYPLA KFTAELGLSP DKAAEVLSQG AHLAAGPDG
Target Information
Hypermethylated in cancer (HIC-1) was originally identified as a target of p53-induced gene expression. HIC-1 is deleted in the genetic disorder Miller-Dieker syndrome (MDS), and its expression is frequently suppressed in leukemia and various cancers due to hypermethylation of specific DNA regions leading to transcriptional silencing. These findings suggest that HIC-1 acts as a tumor suppressor protein mediating transcriptional repression.
HIC-1 is ubiquitously expressed in adult tissues and contains five zinc fingers and an N-terminal broad complex POZ (BTB) domain. In several BTB/POZ proteins, including BCL-6 and PLZF, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex to repress gene transcription. However, HIC-1 does not interact with HDAC components, indicating that its transcriptional repression is independent of the POZ/BTB domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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