Thermo Fisher Scientific HIC1 Monoclonal Antibody (2C1)
Thermo Fisher Scientific의 HIC1 단클론 항체(2C1)는 인간 HIC1 단백질을 인식하는 Mouse IgG2a, kappa 형 항체로 ELISA에 적합합니다. 비결합형 액상 형태이며, -20°C에서 보관합니다. 암 관련 연구 및 HIC1 단백질 발현 분석에 활용됩니다.
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Applications
- ELISA (ELISA)
Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C1 |
| Immunogen | HIC1 (NP_006488.2, 627–705 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
PEGVFAVARL TAEQLSLKQQ DKAAAAELLA QTTHFLHDPK VALESLYPLA KFTAELGLSP DKAAEVLSQG AHLAAGPDG
Target Information
Hypermethylated in cancer (HIC-1) was originally identified as a target of p53-induced gene expression.
HIC-1 is deleted in Miller-Dieker syndrome (MDS) and its expression is often suppressed in leukemia and various cancers due to hypermethylation of specific DNA regions leading to transcriptional silencing.
HIC-1 acts as a putative tumor suppressor protein mediating transcriptional repression. It is ubiquitously expressed in adult tissues and features five zinc fingers and an N-terminal POZ/BTB domain.
In other BTB/POZ proteins (e.g., BCL-6, PLZF), this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex to repress transcription. HIC-1, however, does not interact with HDAC components, suggesting its transcriptional repression is independent of the POZ/BTB domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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