Thermo Fisher Scientific Phospho-beta Catenin (Thr41, Ser45) Polyclonal Antibody
인산화된 Thr41/Ser45 부위의 베타 카테닌을 특이적으로 인식하는 rabbit polyclonal 항체. Western blot 및 면역세포염색(ICC/IF)에 적합. 인간, 생쥐, 랫트 반응성. 1 mg/mL 액상 형태로 PBS/glycerol buffer에 보존. 연구용 전용 시약.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CTNNB1 (Accession P35222), corresponding to amino acid residues around phosphorylated Thr41 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816346 |
Product Specific Information
This antibody detects endogenous levels of beta Catenin only when phosphorylated at Threonine 41/Serine 45.
Target Information
Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and signaling. It links E-cadherin to alpha-catenin, connecting the E-cadherin complex to the actin cytoskeleton. Beta-catenin also interacts with adenomatous polyposis coli protein, microtubules, and multiple signaling pathways (tyrosine kinases, phosphatases, Wnt/Wingless).
It plays a key role in epithelial layer formation, morphogenesis, and regulation of cell proliferation via activation of Lef/Tcf transcription factors. Dysregulation is implicated in various cancers including colorectal, ovarian, breast, liver, lung, gastric, prostate, and skin tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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