Thermo Fisher Scientific Phospho-beta Catenin (Tyr489) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody detects endogenous levels of beta Catenin only when phosphorylated at Tyrosine 489.

Target Information

Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are essential for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells.
Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton.
It also binds to cytoskeletal complexes containing the adenomatous polyposis coli protein and microtubules, and participates in signaling pathways involving tyrosine kinases, phosphatases, and Wnt/Wingless.
This interplay regulates morphogenesis and is linked to various cancers including pilomatrixoma, medulloblastoma, colorectal, ovarian, and other solid tumors.
In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors that stimulate transcription of genes such as cyclin D and c-myc, promoting cell proliferation and tumorigenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.