Thermo Fisher Scientific Phospho-beta Catenin (Tyr489) Polyclonal Antibody
Phospho-beta Catenin (Tyr489) 항체로 인산화된 베타카테닌을 특이적으로 검출. Western blot, IHC, ICC/IF에 사용 가능. Rabbit polyclonal 형식, 1 mg/mL 농도. PBS/glycerol buffer에 보관하며 -20°C에서 안정적 저장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CTNNB1 (Accession P35222), corresponding to amino acid residues around phosphorylated Tyr489 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816347 |
Product Specific Information
This antibody detects endogenous levels of beta Catenin only when phosphorylated at Tyrosine 489.
Target Information
Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are essential for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells.
Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton.
It also binds to cytoskeletal complexes containing the adenomatous polyposis coli protein and microtubules, and participates in signaling pathways involving tyrosine kinases, phosphatases, and Wnt/Wingless.
This interplay regulates morphogenesis and is linked to various cancers including pilomatrixoma, medulloblastoma, colorectal, ovarian, and other solid tumors.
In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors that stimulate transcription of genes such as cyclin D and c-myc, promoting cell proliferation and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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