Thermo Fisher Scientific Phospho-NF2 (Ser518) Polyclonal Antibody
NF2 단백질의 Ser518 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot 및 Immunocytochemistry에 적합. 고순도 정제 및 안정한 PBS/glycerol buffer로 제공. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Phospho-NF2 (Ser518) Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:2,000
- Immunocytochemistry (ICC/IF): 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NF2 (Accession P35240), corresponding to amino acid residues around phosphorylated Ser518 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816348 |
Product Specific Information
Antibody detects endogenous levels of NF2 / Merlin only when phosphorylated at Serine 518.
Target Information
NF2 encodes a protein, Merlin, that is similar to members of the ERM family of proteins linking cytoskeletal components with membrane proteins. Merlin interacts with cell-surface proteins, cytoskeletal regulators, and ion transport proteins.
This gene is highly expressed during embryonic development and in adults is found in Schwann cells, meningeal cells, lens, and nerve. Mutations in NF2 are associated with neurofibromatosis type II, characterized by nervous system and skin tumors and ocular abnormalities.
Two predominant isoforms and several minor isoforms are produced by alternatively spliced transcripts.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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