Thermo Fisher Scientific Androgen Receptor (AR) Polyclonal Antibody
앤드로겐 수용체(AR)를 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ELISA에 적합. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제된 0.5 mg/mL 액상 제품. 핵 내 AR 단백질 검출에 유용하며, 전립선암 등 연구에 활용 가능.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 2–10 µg/mL |
| ELISA | 0.01–0.1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to N-term of human Androgen Receptor (AR) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Prostate Carcinoma
- Cellular location: Nuclear
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors.
It is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT).
Upon ligand binding, the receptor translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
AR signaling is crucial for the development and function of male reproductive organs such as the prostate and epididymis, and also plays roles in nonreproductive tissues including muscle, hair follicles, and brain.
Abnormalities in AR signaling are associated with diseases such as prostate cancer, Kennedy's disease, and male infertility.
Mutations in this gene are linked to complete androgen insensitivity syndrome (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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