Thermo Fisher Scientific ARG1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–1 µg/mL

ELISA

• Tested Dilution: 0.01–0.1 µg/mL

Product Specifications

Product Specific Information

• Positive control: Liver tissue
• Cellular location: Cytoplasm

Target Information

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, the final step in the urea cycle. The resulting polyamines are essential for cell proliferation and detoxification of protein degradation byproducts.
By degrading arginine, Arginase 1 limits NO synthase substrate availability, reducing nitric oxide production.
Arginase 1 is expressed in liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells in both human and mouse. In human, expression occurs in blood neutrophils but not in CCR3+ granulocytes. In mice, Arginase 1 expression marks alternatively activated macrophages (M2a).
It may be expressed in myeloid cells infiltrating tumors and is commonly found in hepatocellular carcinomas.
Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.