Thermo Fisher Scientific TRIM5 alpha/gamma/delta Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:2,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).

Target Information

TRIM5α is a 493 amino acid member of the large tripartite motif protein (TRIM) family. TRIM proteins contain three zinc-binding domains—a RING, a B-box 2, and a coiled-coil domain—and use homomultimerization to identify different cell compartments.
Some TRIM proteins, such as TRIM5α, also possess a carboxy-terminal B30.2 (SPRY) domain and localize to the cytoplasm. TRIM5α mediates innate intracellular retroviral resistance dependent on its carboxy-terminal domain.
The three variable regions of the B30.2 domain form loops that may create a binding surface for the virus. TRIM5α trimerization enhances its affinity for the retroviral capsid and its ability to inhibit infection. The linker region between the coiled-coil and B30.2 domains is required for this trimerization. TRIM5α blocks infection after viral entry into the cell.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

제품 이미지

(이미지 파일명: PA5-76883_TRIM5_alphagammadelta_Q9C035-1_Rabbit.svg, PA5-76883_TRIM5_alphagammadelta_Q9C035-1_Rabbit_PDP.jpeg)