Thermo Fisher Scientific LRAT Polyclonal Antibody
LRAT 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 비결합형 액상 형태로, 안정적인 단백질 검출에 적합합니다.
- 카탈로그번호
- PA536972
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific LRAT Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 148–193 of human LRAT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping conditions | Wet ice |
| RRID | AB_2553841 |
Product Specific Information
This antibody detects endogenous LRAT protein at a molecular weight of approximately 25 kDa (monomer) and 50 kDa (dimer).
Purity is >95% by SDS-PAGE.
Target Information
Lecithin retinol acyltransferase (LRAT) is a membrane-bound enzyme that catalyzes the transfer of an acyl group from the sn-1 position of lecithin to vitamin A, generating all-trans-retinyl esters (tREs) in the liver, lung, and retinal pigmented epithelium.
LRAT also exchanges palmitoyl groups between RPE65 and tREs, which is essential for visual pathway function.
It plays a crucial role in vitamin A mobilization, transport, and storage, as well as visual pigment synthesis.
Loss of LRAT leads to early-onset retinal dystrophy and retinyl ester deficiency, while reduced expression may be linked to invasive bladder cancer.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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