Thermo Fisher Scientific LRAT Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

This antibody detects endogenous LRAT protein at a molecular weight of approximately 25 kDa (monomer) and 50 kDa (dimer).
Purity is >95% by SDS-PAGE.

Target Information

Lecithin retinol acyltransferase (LRAT) is a membrane-bound enzyme that catalyzes the transfer of an acyl group from the sn-1 position of lecithin to vitamin A, generating all-trans-retinyl esters (tREs) in the liver, lung, and retinal pigmented epithelium.
LRAT also exchanges palmitoyl groups between RPE65 and tREs, which is essential for visual pathway function.
It plays a crucial role in vitamin A mobilization, transport, and storage, as well as visual pigment synthesis.
Loss of LRAT leads to early-onset retinal dystrophy and retinyl ester deficiency, while reduced expression may be linked to invasive bladder cancer.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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