Thermo Fisher Scientific Phospho-VANGL2 (Thr78, Ser79, Ser82) Recombinant Rabbit Monoclonal Antibody (7H7C2)

Thermo Fisher Scientific Phospho-VANGL2 (Thr78, Ser79, Ser82) Recombinant Rabbit Monoclonal Antibody (7H7C2)

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:1,000
• ELISA: 1 µg/mL

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Product Specifications

Product Specific Information

• Positive Samples: HeLa, NIH/3T3, C6
• Immunogen Sequence: TSEHS

Target Information

Van Gogh is an alternate name for the Drosophila strabismus protein.
Van Gogh like-2 (VANGL2) is a 521-amino-acid protein in vertebrates similar to strabismus 1 of Drosophila and a component of the frizzled-disheveled tissue polarity pathway. It interacts through its C-terminal region with the N-terminal half of DVL1, DVL2, and DVL3 and is a potent tumor suppressor.

VANGL2 is predominantly involved in:

• Control of early morphogenesis and patterning of axial midline structures
• Development of the neural plate
• Regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea
• Polarization and movement of myocardializing cells via RHOA signaling

It is expressed in a wide range of tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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