Thermo Fisher Scientific Phospho-SPHK1 (Ser225) Polyclonal Antibody
인간 SPHK1의 Ser225 인산화 부위를 특이적으로 인식하는 rabbit polyclonal antibody입니다. Western blot에 적합하며, 액상 형태로 PBS/glycerol buffer에 보존됩니다. 세포 내 SPHK1 인산화 상태 연구에 유용합니다.
- 카탈로그번호
- PA5106040
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-SPHK1 (Ser225) Polyclonal Antibody
Applications
- Western Blot (WB): 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SPHK1 (Accession Q9NYA1), corresponding to amino acid residues around phosphorylated Ser225 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817439 |
Product Specific Information
Antibody detects endogenous levels of SPHK1 only when phosphorylated at Ser225.
Target Information
SPHK1, along with SPHK2, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P).
S1P signals through G-protein coupled receptors and controls diverse cellular processes.
Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer.
SPHK1 catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions.
Inside the cell, S1P acts as a signaling molecule like other sphingolipid metabolites such as ceramide and sphingosine.
S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis.
The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-106040_SPHK1_Q9NYA1-1_Rabbit.svg, PA5-106040_SPHK1_Q9NYA1-1_Rabbit_PDP.jpeg)
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