Thermo Fisher Scientific Phospho-TAB1 (Ser438) Polyclonal Antibody
인간 TAB1의 Ser438 인산화 부위를 표적으로 하는 Rabbit Polyclonal Antibody. Western blot에 1:1,000~1:3,000 희석 비율로 사용 가능. 액상 형태, 농도 1 mg/mL, -20°C 보관. TGF-β 및 MAPK 신호전달 연구용.
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Applications
- Western Blot (WB): 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TAB1 around the phosphorylation site of Ser438 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817445 |
Target Information
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which mediates various intracellular signaling pathways such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts and activates TAK1 kinase. The C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while the N-terminus may act as a dominant-negative inhibitor of TGF beta. TAB1 can also interact with and activate MAPK14/p38alpha, representing an alternative activation pathway contributing to MAPK14 biological responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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