Thermo Fisher Scientific Presenilin 1 Monoclonal Antibody (APS 11)
Presenilin 1 단백질(PS1)을 특이적으로 검출하는 마우스 단클론 항체 APS 11. Western blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. 인간, 생쥐, 흰쥐 및 영장류 시료 반응. Alzheimer’s disease 연구에 적합.
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Thermo Fisher Scientific Presenilin 1 Monoclonal Antibody (APS 11)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 0.75 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC-PFA) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| ELISA | 4.5 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Publications: View 1 publication
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | APS 11 |
| Immunogen | Synthetic peptide corresponding to residues C H(21) L S N T V R S Q N D N R E(34) of human PS1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_325074 |
Product Specific Information
MA1-751 detects presenilin 1 protein (PS1) from mouse, rat, human, and nonhuman primate samples. No cross-reactivity is seen with presenilin 2.
It has been successfully used in immunofluorescence, immunocytochemistry, immunohistochemistry, Western blot, and ELISA procedures.
By Western blot, this antibody detects an ~28 kDa protein representing PS1 N-terminus cleavage product from ST15 cell lysate transfected with human PS1.
In formalin-fixed, paraffin-embedded sections of human brain, this antibody showed strong staining of both plaque cores and dystrophic neurites.
The immunogen is a synthetic peptide corresponding to residues C H(21) L S N T V R S Q N D N R E(34) of human PS1.
Target Information
Presenilin 1 (PS1) is a key component of the γ-secretase complex, involved in proteolytic cleavage within the lipid bilayer. It plays a critical role in generating amyloid peptides associated with Alzheimer’s disease pathogenesis.
PS1 interacts with PEN2, nicastrin, and APH-1 to form the γ-secretase complex, which cleaves proteins such as APP within their intramembrane regions, producing either non-toxic p3 or toxic Aβ peptides.
Accumulation of Aβ peptide is considered a precursor to Alzheimer’s disease. Multiple isoforms of PS1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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