Thermo Fisher Scientific PSEN2 Monoclonal Antibody (APS 21)

Applications and Tested Dilutions

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Product Specifications

Product Specific Information

MA1-753 detects presenilin 2 protein (PS2) from rat, mouse, human, and nonhuman primate samples. No cross-reactivity is seen with presenilin 1.
This antibody has been successfully used in immunofluorescence, Western blot, and ELISA procedures.
By Western blot, it detects an ~28 kDa PS2 N-terminus fragment and a ~46 kDa full-length PS2 from transfected COS-7 cells.
In 4% paraformaldehyde-fixed COS-7 cells transfected with hPS2, MA1-753 shows specific Golgi, nuclear envelope, and ER labeling.
The immunogen is a synthetic peptide corresponding to residues C(31)QEGRQGPEDGENTA(45) of human PS2.

Target Information

Alzheimer’s disease (AD) patients with inherited forms of the disease carry mutations in presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP).
These mutations increase production of the longer amyloid-beta form, the main component of amyloid deposits found in AD brains.
Presenilins are thought to regulate APP processing via gamma-secretase activity and may also be involved in Notch receptor cleavage.
Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.