Thermo Fisher Scientific NeuroD1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:100-1:500

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 160-356 of human NEUROD1 (NP_0024912) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NeuroD1,uniProtId:Q13562-1,ncbiNodeId:9606,antigenRange:160-356,antigenLength:356,antigenImageFileName:PA5-88138_NeuroD1_Q13562-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88138_NeuroD1_Q13562-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.44 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804681

Product Specific Information

Immunogen sequence: GKSPDLVSFV QTLCKGLSQP TTNLVAGCLQ LNPRTFLPEQ NQDMPPHLPT ASASFPVHPY SYQSPGLPSP PYGTMDSSHV FHVKPPPHAY SAALEPFFES PLTDCTSPSF DGPLSPPLSI NGNFSFKHEP SAEFEKNYAF TMHYPAATLA GAQSHGSIFS GTAAPRCEIP IDNIMSFDSH SHHERVMSAQ LNAIFHD

Positive Samples: HepG2, Mouse brain; Cellular Location: Cytoplasm, Nucleus

Target Information

NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6). MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.